12/11/2022 0 Comments Emergency 4 wegberg english![]() External consultants reviewed the guidelines. The Delphi-method was used when there was no or little evidence available. Literature search, critical appraisal and evidence grading were conducted according to the SIGN (Scottish Intercollegiate Guidelines Network) method. Professionals from 10 different European countries developed the guidelines according to the AGREE (Appraisal of Guidelines for Research and Evaluation) method. PKU management differs widely across Europe and therefore these guidelines have been developed aiming to optimize and standardize PKU care. ![]() If left untreated, PKU results in increased phenylalanine concentrations in blood and brain, which cause severe intellectual disability, epilepsy and behavioural problems. Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine metabolism caused by deficiency in the enzyme phenylalanine hydroxylase that converts phenylalanine into tyrosine. ![]()
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